A methodology for the estimation of the fatigue life of thermally buckled composite panels subjected to acoustic loading is proposed. The approach uses existing fatigue damage accumulation models but accounts for both damages created by the snap-throughs and in between snap-throughs. The proposed strategy relies on the decomposition of the response fields, i.e. displacements, stresses, and strains, into “jump” processes (modeling the snap-throughs) and “fluctuation” processes (modeling the vibrations around the buckled states). Further, a computationally efficient technique for the reliable determination of the characteristics of these processes in the presence of an arbitrary number of modes is suggested so that the proposed approach is applicable to both phenomenological studies for design considerations and detailed postmortem analyses. The validation of this strategy to the estimation of the fatigue life of a composite panel is proposed. Finally, parametric studies are planned to evaluate the effects of surface temperature, temperature gradient across the panel, orientation of the fibers, acoustic excitation level (SPL) on the fatigue life.